Confession: I'm not a clean fan. OK maybe the jazzy stuff- that, I can tolerate. Lately, due to a single coil preoccupation, I'm appreciating clean tones. The cleans which contain traces of drive when cranked up. Nick Johnston- that's my best reference. So the adventure requires me to add a pedal into the signal chain because the single coils I'm dealing with are not the high output type; the Ashburn's Bloodline pickups are polite entities. A clean boost is added as seen above, it's a Protone Clean Boost which turns into an overdrive at maximum setting.
What's the benefit of approaching tone from this perspective? It allows the player to clean up the signal via the volume control. Not all pickups-boost combo will give you this luxury, it's a matter of trial & error.